S100A1 Polyclonal Antibody

Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes .These changes allow interactions with specific target proteins and modulate their activity.Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole.

S100A; S100A1; Bpb; NEF; Protein S100-A1; S100; S100 alpha; S100 beta; S100 calcium binding protein A1; S100 calcium binding protein B; S100 calcium-binding protein A1; S-100 protein alpha chain; S100 protein alpha polypeptide; S-100 protein subunit alpha; S100-alpha; S100B; S100beta; S100A1