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AKR1B10-IN-1

AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1].

Product Specifications

CAS Number

[2136579-33-2]

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akr1b10-in-1.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=CC=C(O)C=C2OC1=O)NCCCC3=CC=C(F)C=C3

Molecular Formula

C19H16FNO4

Molecular Weight

341.33

References & Citations

[1]Endo S, et al. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells [published correction appears in J Med Chem. 2018 Feb 8;61 (3) :1380]. J Med Chem. 2017;60 (20) :8441-8455.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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Myosin IIA, Non-muscle, Phosphorylated (Ser1943) (Myosin-9, Myosin Heavy Chain 9, Myosin Heavy Chain, Non-Muscle IIa, Non-Muscle Myosin Heavy Chain IIa, NMMHC II-a, NMMHC-IIA, Cellular Myosin Heavy Chain, Type A, Non-Muscle Myosin Heavy Chain A, NMMHC-A,

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Myosin IIA, Non-muscle, Phosphorylated (Ser1943) (Myosin-9, Myosin Heavy Chain 9, Myosin Heavy Chain, Non-Muscle IIa, Non-Muscle Myosin Heavy Chain IIa, NMMHC II-a, NMMHC-IIA, Cellular Myosin Heavy Chain, Type A, Non-Muscle Myosin Heavy Chain A, NMMHC-A,

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Myosin IIA, Non-muscle, Phosphorylated (Ser1943) (Myosin-9, Myosin Heavy Chain 9, Myosin Heavy Chain, Non-Muscle IIa, Non-Muscle Myosin Heavy Chain IIa, NMMHC II-a, NMMHC-IIA, Cellular Myosin Heavy Chain, Type A, Non-Muscle Myosin Heavy Chain A, NMMHC-A,

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