AKR1B10-IN-1
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1].
Product Specifications
CAS Number
[2136579-33-2]
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1b10-in-1.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=C(O)C=C2OC1=O)NCCCC3=CC=C(F)C=C3
Molecular Formula
C19H16FNO4
Molecular Weight
341.33
References & Citations
[1]Endo S, et al. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells [published correction appears in J Med Chem. 2018 Feb 8;61 (3) :1380]. J Med Chem. 2017;60 (20) :8441-8455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0615608 1.0 µg DNA
DNAJC8P1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
Sign In for Pricing
View Details 
036911-ML405 100 µL
IGF2BP2, CT (IGF2BP2, IMP2, VICKZ2, Insulin-like growth factor 2 mRNA-binding protein 2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2) (MaxLight 405) discontinued
Sign In for Pricing
View Details MBS3900869-01 0.01 mg
Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified
Sign In for Pricing
View Details MBS3900869-02 0.1 mg
Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified
Sign In for Pricing
View Details MBS3900869-03 5x 0.01 mg
Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified
Sign In for Pricing
View Details