TFMB- (R) -2-HG
TFMB- (R) -2-HG is a cell membrane-permeable (R) -2-HG and acute myeloid leukemia (AML) oncogenic factor. TFMB- (R) -2-HG competitively inhibits α-ketoglutarate-dependent dioxygenases such as KDM2B and FTO. TFMB- (R) -2-HG impairs cell differentiation in response to Estrogen withdrawal. TFMB- (R) -2-HG is used in acute myeloid leukemia and glioma research[1][2][3].
Product Specifications
CAS Number
1445700-01-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Estrogen Receptor/ERR; Fat Mass and Obesity-associated Protein (FTO) ; Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tfmb-r-2-hg.html
Concentration
10mM
Purity
98.26
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
O=C([C@@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C13H11F3O4
Molecular Weight
288.22
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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