PROTAC ACC degrader-1

PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC50 = 107.8 μg/mL) . (Structure Note: Pink, Target protein ligand (HY-169009) ; Blue, E3 ligand (HY-10984) ; Black, linker (HY-W007559) [1].

Product Specifications

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/protac-acc-degrader-1.html

Smiles

CC1=C(C2=C(OCCCCCC(NC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C6(CCC(OC)CC6)NC2=O)C=C(C)C=C1

Molecular Formula

C37H42N4O8

Molecular Weight

670.75

References & Citations

[1]Xu Q, et al. Acetyl-CoA Carboxylase Proteolysis-Targeting Chimeras: Conceptual Design and Application as Insecticides. J Agric Food Chem. 2024 Aug 28;72 (34) :18809-18815.