AE-3763
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
Product Specifications
CAS Number
[291778-77-3]
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/AE-3763.html
Purity
99.82
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(O)CN1CCN(CC(N[C@H](C(N2[C@H](C(N[C@@H](C(C)C)C(C(F)(F)F)=O)=O)CCC2)=O)C(C)C)=O)C1=O
Molecular Formula
C23H34F3N5O7
Molecular Weight
549.54
References & Citations
[1]Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17 (21) :7477-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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