Lenalidomide-C5-NH2 (hydrochloride)

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].

Product Specifications

CAS Number

[2595367-27-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenalidomide-c5-nh2-hydrochloride.html

Purity

99.28

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl

Molecular Formula

C18H24ClN3O3

Molecular Weight

365.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61 (2) :462-481.|[2]Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62 (2) :448-466.