Dihydrocytochalasin B

Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis[2]. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings[3].

Product Specifications

CAS Number

[39156-67-7]

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H351

Target

Arp2/3 Complex

Type

Natural Products

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dihydrocytochalasin-b.html

Purity

99.0

Solubility

DMF : 30 mg/mL (ultrasonic; warming) |DMSO : ≥ 20 mg/mL

Smiles

O=C1[C@]2(O3)[C@]([C@@H](C([C@@H](O)[C@]2([H])/C=C/C[C@@H](CCC[C@@H](O)CCC3=O)C)=C)C)([H])[C@H](CC4=CC=CC=C4)N1

Molecular Formula

C29H39NO5

Molecular Weight

481.62

Precautions

H300+H310+H330, H351

References & Citations

[1]Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76 (2) :360-70.|[2]Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33 (2) :143-51.|[3]Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30 (1) :253-62.