Davunetide
Product Specifications
UNSPSC Description
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity[1][2][3].
Target Antigen
Amyloid-β; Microtubule/Tubulin
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/davunetide.html
Purity
99.64
Solubility
DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CCC(N)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCC2)N2C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)=O)=O)=O
Molecular Weight
824.92
References & Citations
[1]Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842.|[2]Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimer's disease-associated rats. Physiol Behav. 2017;174:67-73.|[3]Idan-Feldman A, et al. Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiol Dis. 2011;44(3):327-339.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105066/Davunetide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105066/Davunetide-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
211439-12-2
Available Sizes
Curated Selection
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