Ac-WEHD-AFC

Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation[1].

Product Specifications

CAS Number

[210344-99-3]

UNSPSC

12352209

Target

Caspase; Fluorescent Dye

Type

Peptides

Related Pathways

Apoptosis; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-wehd-afc.html

Solubility

10 mM in DMSO

Smiles

FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC3=CNC4=CC=CC=C34)=O)=O)CC5=CN=CN5)=O)=O)=CC1=O)F

Molecular Formula

C38H37F3N8O11

Molecular Weight

838.74

References & Citations

[1]Katherine Labbé, et al. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity