Human CD16a (158V) (Luc) Jurkat Reporter Cell

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immunotherapy. CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. Previous study indicated that t, CD16a 158V shows a better ADCC in vitro. Acrobiosystems offers a series of NFAT (Luc) Jurkat Reporter Cell specifically designed to assess the potency of specific immunoglobulin for (antibody-dependent cellular cytotoxicity) and (antibody-dependent cell-mediated phagocytosis) . These cells derive from the human T lymphocyte Jurkat cell line and stably express CD16 or CD32, two Fc-gamma receptors (FcγR) for the constant region of immunoglobulin G (IgG) .