DM4-SMCC

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker[1].

Product Specifications

CAS Number

[1228105-52-9]

UNSPSC

12352203

Hazard Statement

H301, H311, H331

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dm4-smcc.html

Purity

96.86

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SC(C5)C(N(CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

Molecular Formula

C54H72ClN5O16S

Molecular Weight

1114.69

Precautions

H301, H311, H331

References & Citations

[1]Singh R, et al. A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved TargetedKilling of Cancer Cells. Mol Cancer Ther. 2016 Jun;15 (6) :1311-20.