Ilmofosine
Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent[1][2].
Product Specifications
CAS Number
83519-04-4
Product Name Alternative
BM41440
UNSPSC
12352211
Hazard Statement
H301
Target
Parasite; PKC
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics; TGF-beta/Smad
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ilmofosine.html
Smiles
CCCCCCCCCCCCCCCCSCC(COC)COP(OCC[N+](C)(C)C)([O-])=O
Molecular Formula
C26H56NO5PS
Molecular Weight
525.77
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Croft SL, et al. Antileishmanial activity of the ether phospholipid ilmofosine. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87 (2) :217-9. |[2]Hofmann J, et al. The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. Biochem Biophys Res Commun. 1994 Mar 15;199 (2) :937-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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