5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1].
Product Specifications
CAS Number
[861214-33-7]
Product Name Alternative
5'-FIO
UNSPSC
12352005
Hazard Statement
H315, H319
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-fluoroindirubinoxime.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(F)C=C2)/C1=C3NC4=C(C=CC=C4)C\3=N/O
Molecular Formula
C16H10FN3O2
Molecular Weight
295.27
Precautions
H315, H319
References & Citations
[1]Choi SJ, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20 (6) :2033-7.|[2]Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13 (1) :253-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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