5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1].

Product Specifications

CAS Number

[861214-33-7]

Product Name Alternative

5'-FIO

UNSPSC

12352005

Hazard Statement

H315, H319

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-fluoroindirubinoxime.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=C(F)C=C2)/C1=C3NC4=C(C=CC=C4)C\3=N/O

Molecular Formula

C16H10FN3O2

Molecular Weight

295.27

Precautions

H315, H319

References & Citations

[1]Choi SJ, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20 (6) :2033-7.|[2]Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13 (1) :253-9.