L-Histidine-13C6,15N3 (hydrochloride hydrate)

L-Histidine-13C6,15N3 hydrochloride hydrate is the 13C- and 15N-labeled L-Histidine hydrochloride hydrate (HY-W014423) . L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable[1][2][3].

Product Specifications

CAS Number

[202468-43-7]

Product Name Alternative

H-His-OH-13C6,15N3 (hydrochloride hydrate)

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-histidine-13c6-15n3-hydrochloride-hydrate.html

Purity

99.53

Solubility

10 mM in DMSO

Smiles

O[13C]([13C@@H]([15NH2])[13CH2][13C]1=[13CH][15N]=[13CH][15NH]1)=O.Cl.O

Molecular Formula

13C6H12Cl 15N3O3

Molecular Weight

218.57

References & Citations

[1]Palomba L, et al., Low levels of hydrogen peroxide and L-histidine induce DNA double-strand breakage and apoptosis. Eur J Pharmacol. 1996 Dec 27;318 (1) :167-73.|[2]Kawahara M, et al., D-histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells. Metallomics. 2013 May;5 (5) :453-60.|[3]Wade A M, et al., Antioxidant characteristics of L-histidine[J]. The Journal of Nutritional Biochemistry, 1998, 9 (6) : 308-315.