Phospho-SEK1/MKK4 (Ser257) Rabbit FITC Conjugate

<strong>Phospho-SEK1/MKK4 (Ser257) Rabbit FITC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018552_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MEK4, SAPKK1, JNKK1, PRKMK4, MAP2K4, SERK1, SKK1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zhang R, Kang KA, Kang SS, Park JW, Hyun JW. Morin (2',3,4',5,7-pentahydroxyflavone) protected cells against γ-radiation-induced oxidative stress Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):63-72._x000D_ 2: Zhang Q, Zhang G, Meng F, Tian H. Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus Neurosci Lett. 2003 Jan 30;337(1):51-5._x000D_ 3: Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DW. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13169-74._x000D_ 4: Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD Cell Death Differ. 2012 Oct;19(10):1623-33._x000D_ 5: Chang AY. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death J Biomed Sci. 2012 Nov 17;19(1):96._x000D_ 6: Kundumani-Sridharan V, Subramani J, Das KC. Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells J Biol Chem. 2015 Jul 10;290(28):17505-19._x000D_ 7: Crittenden PL, Filipov NM. Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase-1 in microglial cells J Appl Toxicol. 2011 Jan;31(1):1-10._x000D_ 8: Ogawa H, Murayama A, Nagata S, Fukunaga R. Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases J Biol Chem. 2003 Jan 31;278(5):2921-7._x000D_ 9: Ahn YH, Kurie JM. MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch J Biol Chem. 2009 Oct 23;284(43):29399-404._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/9620683">10: Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development Immunity. 1998 May;8(5):625-34. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-SEK1/MKK4 (Ser257) Rabbit FITC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>