Cyclofenil
Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity[1][2].
Product Specifications
CAS Number
2624-43-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dengue Virus; Estrogen Receptor/ERR; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/cyclofenil.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(OC1=CC=C(/C(C2=CC=C(OC(C)=O)C=C2)=C3CCCCC\3)C=C1)=O
Molecular Formula
C23H24O4
Molecular Weight
364.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Tohma D, et al. An estrogen antagonist, cyclofenil, has anti-dengue-virus activity. Arch Virol. 2019 Jan;164 (1) :225-234.|[2]Arrieta-Cruz I, et al. Estrogen Receptors Alpha and Beta in POA-AHA Region Regulate Asymmetrically Ovulation. Cell Mol Neurobiol. 2019 Nov;39 (8) :1139-1149.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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