Sildenafil-d3

Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

Product Specifications

CAS Number

[1126745-90-1]

Product Name Alternative

UK-92480-d3

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCOC1=C(C=C(S(N2CCN(CC2)C([2H])([2H])[2H])(=O)=O)C=C1)C(NC3=C4N(N=C3CCC)C)=NC4=O

Molecular Formula

C22H27D3N6O4S

Molecular Weight

477.59

References & Citations

[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7|[2][2].Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.|[3][3]. Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.