Sheep anti Human HER2/neu
Product Specifications
Background
c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein.
CAS Number
9007-83-4
Synonyms
p185erbB2, MLN 19, CD340, c-ErbB-2
UniProt
P04626
Host
Sheep
Species Reactivity
Human
Isotype
IgG
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Field of Research
Signal Transduction
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
Antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Stancovski, I et. al. 'Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.' Proc. Natl. Acad. Sci USA, 1991, 88(19):8691-5.
2. Hurwitz E et. al. 'Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.' Proc. Natl. Acad. Sci USA, 1995, 92(8):3353-7.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
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