1,3-Dimethyluracil

1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively[1][2].

Product Specifications

CAS Number

[874-14-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-3-dimethyluracil.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN1C=CC(=O)N(C)C1=O

Molecular Formula

C6H8N2O2

Molecular Weight

140.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Stoessel D, et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Front Aging Neurosci. 2018 Mar 5;10:51.|[2]Güney M, et al. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett. 2015 Aug 15;25 (16) :3261-3.