(S, R, S) -AHPC-PEG3-N3

(S, R, S) -AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S, R, S) -AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1797406-80-4]

Product Name Alternative

VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3 ligase_Ligand-Linker_Conjugates_1.html

Purity

99.67

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]

Molecular Formula

C30H43N7O7S

Molecular Weight

645.77

Precautions

H302, H315, H319, H335

References & Citations

[1]CIULLI, Alessio, et al. DERIVATIVES OF 1-[ (CYCLOPENTYL OR 2-PYRROLIDINYL) CARBONYLAMINOMETHYL]-4- (1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES. WO2016146985A1.|[2]Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10 (8) :1770-7.