MMAD
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs) .
Product Specifications
CAS Number
203849-91-6
Product Name Alternative
Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MMAD.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3
Molecular Formula
C41H66N6O6S
Molecular Weight
771.06
Precautions
H302, H315, H319, H335
References & Citations
[1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8 (2) :114-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
Frequently Asked Questions
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