Aditoprime (Standard)
Aditoprime (Standard) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3].
Product Specifications
CAS Number
56066-63-8
Product Name Alternative
Aditoprim (Standard)
UNSPSC
12352005
Target
Antifolate; Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aditoprime-standard.html
Smiles
NC1=NC=C(CC2=CC(OC)=C(N(C)C)C(OC)=C2)C(N)=N1
Molecular Formula
C15H21N5O2
Molecular Weight
303.36
References & Citations
[1]Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988;35 (2) :114-120. |[2]Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017;7:41370. Published 2017 Feb 1. |[3]Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015;35 (12) :1531-1538.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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