MPO-IN-7
MPO-IN-7 (compound MDC) is a myeloperoxidase inhibitor with the IC50 values of 41 μM, 25 μM and 4.5 μM towards α-Glucosidase, dipeptidyl peptidase-4 and myeloperoxidase, respectively. MPO-IN-7 shows antioxidant and anti-inflammatory activity in vitro[1].
Product Specifications
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Glutathione Peroxidase; Glycosidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mpo-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NCC3=CC=C(OC)C=C3
Molecular Formula
C16H14N2O6
Molecular Weight
330.29
References & Citations
[1]Rajan R, et al. Synthesis, Structural Elucidation, In Silico and In Vitro Studies of New Class of Methylenedioxyphenyl-Based Amide Derivatives as Potential Myeloperoxidase Inhibitors for Cardiovascular Protection. ACS Omega. 2024 Feb 7;9 (7) :7850-7868.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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