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SM-1295

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].

Product Specifications

CAS Number

1562375-46-5

UNSPSC

12352005

Target

Apoptosis; IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sm-1295.html

Purity

98.71

Solubility

DMSO : 310 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CC[C@@](CCN(C(CC2=CC=CC=C2)=O)C[C@@H]3NC([C@@H](NC)C)=O)([H])N1C3=O)NCC4=CC=C(Br)C=C4

Molecular Formula

C29H36BrN5O4

Molecular Weight

598.53

References & Citations

[1]Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9 (4) :994-1002.|[2]Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62 (12) :5750-5772.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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