DI-82
Product Specifications
UNSPSC Description
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/di-82.html
Smiles
NC1=NC(S[C@H](C)C(N=C2C(C=C3OCCNS(=O)(C)=O)=CC=C3OC)=C(S2)C)=NC(N)=C1
Molecular Weight
510.65
References & Citations
[1]Julian Nomme, et al. Structure-guided Development of Deoxycytidine Kinase Inhibitors With Nanomolar Affinity and Improved Metabolic Stability. J Med Chem. 2014 Nov 26;57(22):9480-94.|[2]Helena Almqvist, et al. CETSA Screening Identifies Known and Novel Thymidylate Synthase Inhibitors and Slow Intracellular Activation of 5-fluorouracil. Nat Commun. 2016 Mar 24;7:11040.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136499/DI-82-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136499/DI-82-SDS-MedChemExpress.pdf
CAS Number
1638148-50-1
Available Sizes
Curated Selection
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