1,3,7-Trimethyluric acid

1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort[1].

Product Specifications

CAS Number

[5415-44-1]

Product Name Alternative

SC-39026; Declaben

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Drug Metabolite; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-3-7-trimethyluric-acid.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1C)N(C)C2=C(N(C)C(N2)=O)C1=O

Molecular Formula

C8H10N4O3

Molecular Weight

210.19

Precautions

H315, H319, H320

References & Citations

[1]Y Benchekroun, et al. Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. J Chromatogr B Biomed Sci Appl. 1997 Jan 24;688 (2) :245-54.|[2]Madelé van Dyk, et al. Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. Eur J Clin Pharmacol. 2019 Sep;75 (9) :1211-1218.