Abemaciclib metabolite M2
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
Product Specifications
CAS Number
[1231930-57-6]
Product Name Alternative
LSN2839567
UNSPSC
12352005
Target
CDK; Drug Metabolite
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abemaciclib-metabolites-m2.html
Purity
99.75
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C
Molecular Formula
C25H28F2N8
Molecular Weight
478.54
References & Citations
[1]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14) .|[2]CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Available Sizes
Curated Selection
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