Ac2-12 (TFA)
Product Specifications
UNSPSC Description
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ac2-12-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.CC(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
1465.59
References & Citations
[1]L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9.|[2]M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1099A/Ac2-12-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1099A/
Clinical Information
No Development Reported
Curated Selection
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