Ac2-12 (TFA)

Ac2-12 TFA, an annexin/lipocortin 1 (LC1) -mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

Product Specifications

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac2-12-tfa.html

Solubility

H2O

Smiles

OC(C(F)(F)F)=O.CC(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C65H95F3N14O19S

Molecular Weight

1465.59

References & Citations

[1]L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95 (24) :14535-9.|[2]M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158 (6) :1969-73.