PAOPA
PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists[1].
Product Specifications
CAS Number
[114200-31-6]
UNSPSC
12352005
Hazard Statement
H302
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/paopa.html
Purity
98.09
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CCCN1)N[C@H]2C(N(CC2)CC(N)=O)=O
Molecular Formula
C11H18N4O3
Molecular Weight
254.29
Precautions
H302
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor
Available Sizes
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