Etifoxine

Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].

Product Specifications

CAS Number

[21715-46-8]

Product Name Alternative

HOE 36-801

UNSPSC

12352005

Hazard Statement

H302, H401

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/etifoxine.html

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C2C(C(C3=CC=CC=C3)(C)OC(NCC)=N2)=C1

Molecular Formula

C17H17ClN2O

Molecular Weight

300.78

Precautions

H302, H401

References & Citations

[1]Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA (A) receptors in rodents. Neurosci Res. 2002 Oct;44 (2) :167-72.|[2]Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA (A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45 (3) :293-303.|[3]Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21 (6) :457-70.