(Rac) -Deox B 7,4
(Rac) -Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac) -Deox B 7,4 possesses nanomolar anti-leukemic activity[1].
Product Specifications
CAS Number
674786-37-9
Product Name Alternative
(Rac) -Deoxysappanone B 7,4' dimethyl ether
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-deox-b-7-4.html
Smiles
O=C1C(COC2=C1C=CC(OC)=C2)CC3=CC=C(C(O)=C3)OC
Molecular Formula
C18H18O5
Molecular Weight
314.33
References & Citations
[1]Dannie Bernard, et al. Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis. 2015 Jul;20 (7) :948-59.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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