Tafamidis
Transthyretin Dissociation Inhibitor
Product Specifications
Background
Tafamidis functions as a chaperone that stabilizes the correctly folded tetrameric form of the transthyretin (TTR) protein by binding in one of the two thyroxine-binding sites of the tetramer (1). In drug form, it is used to delay impairment of peripheral nerve function in adults with familial amyloid polyneuropathy.
CAS Number
594839-88-0
Product Name Alternative
2- (3,5-Dichlorophenyl) -1,3-Benzoxazole-6-Carboxylic Acid, FX-1006, 2- (3,5-Dichlorophenyl) -6-benzoxazole carboxylic acid
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (25 mg/ml, warm)
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.1
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Said G, Grippon S, Kirkpatrick P. (2012). Nature Reviews. Drug Discovery. 11(3): 185–186.
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