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Pomalidomide

E3 Ubiquitin Ligase Inhibitor

Product Specifications

Background

Pomalidomide, a derivative of thalidomide, is an inhibitor TNF-α production (1), enhances the activity of T cells and natural killer cells and enhances antibody- dependent cellular cytotoxicity. It also may inhibit tumor angiogenesis, and promote cell cycle arrest (2).

CAS Number

19171-19-8

Product Name Alternative

1,3-Dioxo-2- (2,6-dioxopiperidin-3-yl) -4-aminoisoindoline; 3-amino-N- (2,6-dioxo-3-piperidyl) phthalamide

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Cancer Growth Inhibitors | Angiogenesis Inhibitors | Cell Signaling | Post-translational Modifications | Ubiquitination | E3 Ubiquitin Ligases

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.005

Format

Yellow powder

Solubility

May be dissolved in DMSO (50 mg/ml)

Molecular Formula

C13H11N3O4

Molecular Weight

273.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. D'Amato R., Lentzsch S, Anderson K.C. ad Rogers M.S. (2001) Seminars in Oncology. 28(6): 597-601. 2. Fujiwara Y., et al. (2018) Cancer Research. DOI: 10.1158/0008-5472.CAN-18-1781

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