Pomalidomide
E3 Ubiquitin Ligase Inhibitor
Product Specifications
Background
Pomalidomide, a derivative of thalidomide, is an inhibitor TNF-α production (1), enhances the activity of T cells and natural killer cells and enhances antibody- dependent cellular cytotoxicity. It also may inhibit tumor angiogenesis, and promote cell cycle arrest (2).
CAS Number
19171-19-8
Product Name Alternative
1,3-Dioxo-2- (2,6-dioxopiperidin-3-yl) -4-aminoisoindoline; 3-amino-N- (2,6-dioxo-3-piperidyl) phthalamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Cancer Growth Inhibitors | Angiogenesis Inhibitors | Cell Signaling | Post-translational Modifications | Ubiquitination | E3 Ubiquitin Ligases
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Yellow powder
Solubility
May be dissolved in DMSO (50 mg/ml)
Molecular Formula
C13H11N3O4
Molecular Weight
273.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. D'Amato R., Lentzsch S, Anderson K.C. ad Rogers M.S. (2001) Seminars in Oncology. 28(6): 597-601. 2. Fujiwara Y., et al. (2018) Cancer Research. DOI: 10.1158/0008-5472.CAN-18-1781
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