Rucaparib phosphate

PARP Inhibitor

Product Specifications

Background

Rucaparib is a PARP1, PARP2 and PARP3 inhibitor and inhibits PARP-mediated DNA repair (1). It is being developed for ovarian, prostate and bladder cancers (2, 3).

CAS Number

459868-92-9

Product Name Alternative

8-fluoro-1,3,4,5-tetrahydro-2-[4-[ (methylamino) methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, phosphate; AG-14699; PF01367338

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors

Purity

>98% (HPLC) ; NMR (Conforms)

Weight

0.005

Format

Yellow powder

Solubility

May be dissolved in DMSO (25 mg/ml)

Molecular Formula

C19H18FN3O * H3PO4

Molecular Weight

421.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. https://pubchem.ncbi.nlm.nih.gov/compound/rucaparib 2. Dockery L.E., Gunderson C.C., and Moore K.N. (2017) Onco Target Ther. 10: 3029-3037. 3. Syed Y.Y. (2017) Drugs. 77(5): 585-592.