P7C3

NAMPT activator

Product Specifications

Background

P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity (1). Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis (2). Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson's disease (3). Restores hippocampal neurogenesis in a mouse model of Down Syndrome (4). The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD (5). Active in vivo.

Product Name Alternative

1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol; AK34095

UNSPSC

41116105

Source

Synthetic

Purity

>98% (TLC); NMR (Conforms)

Weight

0.005

Format

Off-white powder

Solubility

May be dissolved in DMSO (40 mg/ml)

Molecular Formula

C21H18Br2N2O

Molecular Weight

474.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. AA Pieper et al. Cell 2010 142:39 2. T Tesla et al. Proc. Natl. Acad. Sci. USA 2012 109:17016 3. H De Jesus-Cortes et al. Proc. Natl. Acad. Sci. USA 2012 109:17010 4. SE Latchney et al. Neurosci. Lett. 2015 591:86 5. G Wang et al. Cell 2014 158:1324