P7C3

P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity (1). Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis (2). Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson's disease (3). Restores hippocampal neurogenesis in a mouse model of Down Syndrome (4). The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD (5). Active in vivo.

Cancer | Apoptosis | Neuroscience | Neurodegeneration | Alzheimer's Disease | Parkinson's Disease | Cardiovascular System | Angiogenesis | Cardiovascular Growth Factors | VEGF | VEGF Receptors | Atherosclerosis | Diabetes Associated | Cancer | Cell Cycle | p53 Pathway

1. AA Pieper et al. Cell 2010 142:39 2. T Tesla et al. Proc. Natl. Acad. Sci. USA 2012 109:17016 3. H De Jesus-Cortes et al. Proc. Natl. Acad. Sci. USA 2012 109:17010 4. SE Latchney et al. Neurosci. Lett. 2015 591:86 5. G Wang et al. Cell 2014 158:1324