Vildagliptin
Anti-diabetic agent
Product Specifications
Background
Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model (3). Displays protective effects on βcells by inhibition of ER stress in a mouse model (4). Clinically useful antidiabetic agent.
CAS Number
274901-16-5
Product Name Alternative
(S) -1-[N- (3-hydroxy-1-adamantyl) glycyl]pyrrolidine-2-carbonitrile; LAF237
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Atherosclerosis | Diabetes Associated
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)
Molecular Formula
C17H25N3O2
Molecular Weight
303.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. B Balas et al. J. Clin. Endocrinol. Metab. 2007 92:1249
2. B Ahren et al. J. Clin. Endocrinol. Metab. 2004 89:2078
3. J Kosaraju et al. J. Pharm. Pharmacol. 2013 65:1773
4. S Shimizu et al. J. Mol. Endocrinol. 2012 49:125
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