Vildagliptin

Anti-diabetic agent

Product Specifications

Background

Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model (3). Displays protective effects on βcells by inhibition of ER stress in a mouse model (4). Clinically useful antidiabetic agent.

Product Name Alternative

(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237

UNSPSC

41116105

Source

Synthetic

Purity

>98% (HPLC); NMR (Conforms)

Weight

0.005

Format

White powder

Solubility

May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)

Molecular Formula

C17H25N3O2

Molecular Weight

303.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. B Balas et al. J. Clin. Endocrinol. Metab. 2007 92:1249 2. B Ahren et al. J. Clin. Endocrinol. Metab. 2004 89:2078 3. J Kosaraju et al. J. Pharm. Pharmacol. 2013 65:1773 4. S Shimizu et al. J. Mol. Endocrinol. 2012 49:125