What is the catalog number for FPS-ZM1?

The catalog number for FPS-ZM1 is SIH-561-5MG.

What sizes are available for FPS-ZM1?

FPS-ZM1 is available in the following size(s): 5 mg.

FPS-ZM1 is currently made to order / not held in immediate stock. Contact us for lead time.

FPS-ZM1

RAGE antagonist

Product Specifications

Background

A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo (1,2). In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage (3). It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling (4). Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia (5). BBB permeable.

CAS Number

945714-67-0

Product Name Alternative

4-Chloro-N-cyclohexyl-N- (phenylmethyl) benzamide

UNSPSC

41116105

Type

Antagonist

Source

Synthetic

Field of Research

Neuroscience | Neurodegeneration | Parkinson's Disease | Alzheimer's Disease

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.005

Format

White powder

Solubility

May be dissolved in DMSO (30 mg/ml); or Ethanol (25 mg/ml)

Molecular Formula

C20H22ClNO

Molecular Weight

327.1

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. R Deane et al. J. Clin. Invest. 2012 122:1377 2. Y Hong et al. Neurochem. Res. 2016 41:1192 3. F Yang et al. Stroke 2015 46:1328 4. D Li et al. Neurosci. Lett. 2015 609:109 5. C Shen et al. Neurochem. Res. 2017 June 29 epub