FPS-ZM1
RAGE antagonist
Product Specifications
Background
A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo (1,2). In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage (3). It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling (4). Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia (5). BBB permeable.
CAS Number
945714-67-0
Product Name Alternative
4-Chloro-N-cyclohexyl-N- (phenylmethyl) benzamide
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Parkinson's Disease | Alzheimer's Disease
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (30 mg/ml); or Ethanol (25 mg/ml)
Molecular Formula
C20H22ClNO
Molecular Weight
327.1
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. R Deane et al. J. Clin. Invest. 2012 122:1377
2. Y Hong et al. Neurochem. Res. 2016 41:1192
3. F Yang et al. Stroke 2015 46:1328
4. D Li et al. Neurosci. Lett. 2015 609:109
5. C Shen et al. Neurochem. Res. 2017 June 29 epub
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