Ferrostatin-1
Ferroptosis Inhibitor
Product Specifications
Background
Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3). It has also been shown to mitigate rotenone-induced a-synuclein aggregation (4).
CAS Number
347174-05-4
Product Name Alternative
Ethyl 3-amino-4- (cyclohexylamino) benzoate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.025
Format
Tan powder
Solubility
Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)
Molecular Formula
C15H22N2O2
Molecular Weight
262.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Dixon S.J., et al. (2012) Cell. 149: 1060.
2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732.
3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551. 4. P Kabiraj et al; Protein J., 2015 34; 349
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