What is the catalog number for Fingolimod (FTY720 Hydrochloride)?

The catalog number for Fingolimod (FTY720 Hydrochloride) is SIH-523-25MG.

What sizes are available for Fingolimod (FTY720 Hydrochloride)?

Fingolimod (FTY720 Hydrochloride) is available in the following size(s): 25 mg.

Is Fingolimod (FTY720 Hydrochloride) in stock?

Fingolimod (FTY720 Hydrochloride) is currently made to order / not held in immediate stock. Contact us for lead time.

Fingolimod (FTY720 Hydrochloride)

S1P Receptor Modulator

Product Specifications

Background

FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).

CAS Number

162359-56-0

Product Name Alternative

2-Amino-2-[2- (4-octylphenyl) ethyl]-1,3-propanediol, hydrochloride; Fingolimod

UNSPSC

41116105

Type

Agonist

Source

Synthetic

Field of Research

Cell signaling | Neuroscience | Neurodegeneration | Parkinson's Disease

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.025

Format

White solid

Solubility

Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)

Molecular Formula

C19H34ClNO2

Molecular Weight

343.9

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60. 2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.