SB431542
ALK4,5 and 7 kinase inhibitor
Product Specifications
Background
SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor, activin receptor-like kinases. It has been shown to inhibit ALK4, 5, and 7.
CAS Number
301836-41-9
Product Name Alternative
SB 431542, 4- (5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl) -benzamide hydrate, 4-[4- (1,3-Benzodioxol-5-yl) -5- (2-pyridinyl) -1H-imidazol-2-yl]-benzamide hydrate, 4-[4- (3,4-Methylenedioxyphenyl) -5- (2-pyridyl) -1H-imidazol-2-yl]-benzamide hydrate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
Yellow solid
Solubility
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Molecular Formula
C22H16N4O3
Molecular Weight
384.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Laping N.J., et al. (2002) Mol. Pharm. 62(1): 58–64.
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