SB216763
GSK-3 kinase inhibitor
Product Specifications
Background
SB216763 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor. It inhibits both human GSK-3α and GSK-3β. SB216763 has been shown to stimulate glycogen synthesis in human liver cells and mimic other actions of insulin. SB216763 is cell-permeable and ATP-competitive.
CAS Number
280744-09-4
Product Name Alternative
SB 216763, 3- (2,4-Dichlorophenyl) -4- (1-methyl-1H-indol-3-yl) -1H-pyrrole-2,5-dione
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.005
Format
Orange solid
Solubility
Soluble in DMSO (>25 mg/ml)
Molecular Formula
C19H12Cl2N2O2
Molecular Weight
371.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Culbert A.A., et al. (2001) FEBS Letters. 507(3): 288–294. 2. Coghlan M.P., et al. (2000) Chem. Biol. 7(10): 793–803.
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