PMA
Protein Kinase C Activator
Product Specifications
Background
PMA (Phorbol 12-myristate 13-acetate) is a phorbol ester. It is used experimentally as a reversible protein kinase C (PKC) activator. It has been shown to be a potent tumor promoter.
CAS Number
16561-29-8
Product Name Alternative
Phorbol 12-myristate 13-acetate
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cell Signaling
Purity
≥99% (TLC)
Weight
0.005
Format
Colorless amorphous film or foam
Solubility
Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers
Molecular Formula
C36H58O8
Molecular Weight
616.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Murphy T. V., Prountzos C., Kotsonis P., Iannazzo L., & Majewski H. (1999). Euro.J. Pharm. 381(1): 77–84.
2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847–7851.
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