PD325901
MEK kinase inhibitor
Product Specifications
Background
PD325901 is a potent MEK1 and MEK2 inhibitor. Specifically, it has been shown to suppress phosphorylation of ERK1/2 in murine colon 26 cells, as well as, its downstream target, ribosomal S6 kinase, in a dose-dependent manner.
CAS Number
391210-10-9
Product Name Alternative
PD 0325901, PD-325901, N-[ (2R) -2,3-Dihydroxypropoxy]-3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino]-benzamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
Off-white solid
Solubility
Soluble to 25 mM in DMSO
Molecular Formula
C16H14F3IN2O4
Molecular Weight
482.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Barrett S.D., et al. (2008) Bioorganic. Med. Chem. Letters. 18(24): 6501–6504. 2. Ciuffreda L., et al. (2009) Neoplasia. 11(8): 720–731.
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