LY364947
ALK5 kinase inhibitor
Product Specifications
Background
LY364947 is a potent and selective inhibitor of TGF-β type-1 receptor kinase. Specifically, it inhibits TGF-β signaling and gene transcription. LY364947 is cell permeable and ATP-competitive.
CAS Number
396129-53-6
Product Name Alternative
LY 364947, HTS 466284, ALK5 Inhibitor I, 4-[3- (2-pyridinyl) -1H-pyrazol-4-yl]-quinoline, HTS 466284, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
Yellow to brown solid
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C17H12N4
Molecular Weight
272.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vogt J., Traynor R., & Sapkota G.P. (2011) Cell. Signal. 23(11): 1831–1842.
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